Thursday, November 21
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Tableting and Encapsulation

Granulation in the Pharmaceutical Industry

Granulation in the Pharmaceutical Industry

Medicine, Tableting and Encapsulation
In the Pharmaceutical industry, Granulation can be defined as the act or process in which primary powder particles are adhered to form larger, multi-particle entities. Typically during the production of tablets and capsules, granules are made as an intermediate product and have a usual size range between 0.2 to 0.5 mm, while larger granules are used as a dosage form. Granulation particularly starts after initial dry mixing of the required powdered ingredients so that there is a consistent distribution of each ingredient through the mix. But!!!! Why Particularly Only Me? There are various reasons for choosing the granulation method out of the various tablets manufacturing process. To avoid segregation of the components of the powder mix: Please, don’t blend me with them!!! Se...
Why is Good Tablet Design so Important and How to Achieve it?

Why is Good Tablet Design so Important and How to Achieve it?

Combinatorial Chemistry, Drug Development, Pharmaceutical Chemicals and Intermediates, Pharmaceutical Excipients and Drug Formulation, Tableting and Encapsulation
Detailed design of pharmaceutical and nutraceutical tablets is essential in order to produce robust tablets with bespoke designs. Tablet manufacturers should not overlook tablet design because it is key to the quality of the end product. “With sufficient fore-thought and consideration, most potential tablet making problems can be eliminated at the early stage of design. ” I Holland. Good tablet design is extremely important; it has an impact upon anti-counterfeiting, tooling strength,tablet coating, durability and functionality. Good tablet design helps to avoid downstream manufacturing problems such as tablet sticking, picking, lamination, capping and premature tooling failures. It is essential to consider these at the beginning of the process, ensuring a problem free, high quality, end...