Pharmaceutical Research and Development

Jul112017 by Pharmaceutical TechNo Comments

The Future of Pharmaceuticals

Biotechnology, Pharmaceutical Research and Development

The inter linking of medicine and technology is paving way for newer opportunities in pharmaceutical medication, surgery, and health monitoring. Medicine is increasingly being interspersed with fields such as computer science, nanotechnology and biotechnology to give hybrid fields that are slowly taking over traditional pharmaceuticals. Some of these fields are set to redefine the future of pharmaceuticals. Precision Medicine Precision medicine is a field that attempts at discovering the biological basis of disease using clinical and molecular information of a patient, obtained by converting DNA into data through genome sequencing. This data is used for identifying specific gene abnormalities that help understand which types of patients a drug would be most effective on, an...

Mar132017 by Pharmaceutical TechNo Comments

How is Calibration Carried Out in Pharmaceutical Applications?

FDA Approved Devices, Laboratory Instrumentation, Pharma Industry, Pharmaceutical Research and Development

It goes without saying that calibration is extremely important in the manufacturing process to produce high-quality products. The importance of calibration in the pharmaceutical industry is equally high as low-quality products put the lives of consumers at risk. Instrument calibration and accuracy is very critical to product safety and quality. At the same time, one has to ensure compliance. Strict calibration practices will not only guarantee a safe product but also help in minimizing costs that are associated with damaged batches and associated fines. Importance of Instrument Calibration in Pharmaceutical Applications Instrumentation calibration and equipment validation are responsible for determining the accuracy and performance of the instruments and sensors used in pharmaceutical ap...

Aug172016 by Pharmaceutical TechNo Comments

Using Supply Chain Technology to Improve Pharmaceutical Profit Margins

Pharma Industry, Pharmaceutical Research and Development

The pharmaceutical industry is one of the most competitive on the planet. The global pharmaceutical industry was estimated to be worth $1 trillion in 2014. While there have been tremendous profits to be earned over the years, and still great potential for the future, the business is not without its constraints. According to 2016 figures from PhRMA, it takes anywhere from 10 to 15 years to develop a drug and less than 12 percent of drugs entering clinical trials result in an approved medicine. Development costs are nearly 20 percent of a company's sales. Because these R&D costs eat into profits, pharmaceutical firms must find ways to produce better margins on the production side. One way to do this is by employing various supply chain technology solutions. Improved Forecasting ...

May312016 by Pharmaceutical TechNo Comments

Personalised Cell Therapy

BioPharma, Biotechnology, Pharmaceutical Quality Assurance, Pharmaceutical Research and Development

Personalised treatment Personalised medical treatment has matured to integrate into biopharmaceutical drug development pathways. This type of treatment targets patient/s with a specific drug that matches the specific disease physiopathology and/or patient characteristics e.g. genomic profile, and disease prevalence/severity. Personalised medicine has been generally developed in niche indications or conditions with high unmet need. Cell therapy, transplantation and the HLA matching Cell therapy uses cellular entities as prophylactic or therapeutic drugs/treatments. An ancestor of today’s cell therapy is transplanting hematopoietic stem cells to reset immune systems after intensive leukaemia chemotherapy. Treatment personalisation is essential to match the graft to the recipient(HLA match...

May292016 by Pharmaceutical TechNo Comments

Medical Writing Services in Asia: Recent Developments and Trends

Pharmaceutical Research and Development

Medical writing growth in Asia Medical writing in Asia is an emerging profession and the demand for professional writing skills is on the rise. As such, medical writing hubs in locations such as China, Japan and India have been established to meet the growing need for experienced writers in these locations. China: The Chinese pharmaceutical market is projected to become the 2nd largest globally by 2016, and there is increasing demand for studies to launch new products in China. There are no accurate data on the size of the pool of medical writers in China, but recent informal estimates vary between 50 and 100 dedicated medical writers across CROs and biopharmaceutical companies. For comparison with established markets, there are over 5,000 members registered with the American Medical...

Apr192016 by Pharmaceutical TechNo Comments

Clinical Trials on tissues of human heart now possible in UK

Biotechnology, Clinical Trials, Drug Development, Pharmaceutical Research and Development

A UK based new start-up is developing a unique method for testing out the impact of drugs on the cardio-vascular system without resorting to animal testing or through clinical trials of an early-stage human. The company we are talking about is Inocardia, a spin-out from the University of Coventry. Having attracted sufficient funding from the Mercia Fund Management, this organization is still in the process of shaping up the model and commercializing their line of business. The model that they use takes up samples of the human heart attached to a rig. The cardiac tissue is elongated and contracted through electric impulse stimulation so as to mimic a working human heart.Drugs to be trialed are then administered to the tissue to keep a track of adverse effects – a test that could have been...

Apr152016 by Pharmaceutical TechNo Comments

Preventing HIV/AIDS by Using Liquid Silicone Rubber

Cure & Prevention, Pharmaceutical Research and Development

HIV/AIDS. True that it isn’t much talked about these days as cancer. But the World Health Organisation still bears data that shows about 34 million people around the globe in 2011 managed to breathe air carrying this disease and 1.7 million lost their lives. It is definitely one of the most fatal diseases that has engulfed humanity since it was first detected. There could be some good news: a relatively recent tool that could help to fight back HIV/AIDS is known to be in the Stage III clinical testing being carried out by the US FDA. It constitutes an anti-viral drug that is mixed in a two-component liquid silicone rubber (LSR) that is injection molded into a vaginal ring that releases the drug. A highly advanced combining process was customized for this drug. The machine, metering syst...

Mar212016 by Pharmaceutical TechNo Comments

Weighing and Dispensing Process and Technology in Pharma Industries

Drug Development, Pharmaceutical Chemicals and Intermediates, Pharmaceutical Excipients and Drug Formulation, Pharmaceutical Instrumentation and Controls, Pharmaceutical Quality Assurance, Pharmaceutical Research and Development

Weighing and dispensing process in pharma industries occupies a high priority position. Over the last decades, increased regulations on the manufacturing processes in pharma manufacturing industries led the focus and result is the advanced technology and stringent policies and frameworks. The pharmaceutical companies can increase the speed and accuracy of their operations with weigh and dispense process technology. While, weighing and dispensing of solids and liquids is a very common activity throughout the pharmaceutical industry processes. Traditionally, workers dispense pharma materials by hand-scooping solids and pumping or pouring liquids. This is generally conducted in a warehouse during chemical production or in a pharmacy during pharmaceutical dosage-form manufacturing. The chanc...

Feb252016 by Pharmaceutical TechNo Comments

Clinical Research: Ethical or Unethical?

Clinical Trials, Drug Development, Pharmaceutical Excipients and Drug Formulation, Pharmaceutical Research and Development

Everybody believes that informed consent makes clinical research ethical. However, informed consent is neither necessary nor sufficient for ethical clinical research. Drawing on the basic philosophies underlying major codes, declarations, and other documents relevant to research with human subjects, The aspects which make Clinical Research Ethical: Value: enhancements of health or knowledge must be derived from the research; Scientific validity: the research must be methodologically rigorous. Fair subject selection: scientific objectives, not vulnerability or privilege, and the potential for and distribution of risks and benefits, should determine communities selected as study sites and the inclusion criteria for individual subjects. Favorable risk-benefit ratio: withi...