Drug Development

Apr192016 by Pharmaceutical TechNo Comments

Clinical Trials on tissues of human heart now possible in UK

Biotechnology, Clinical Trials, Drug Development, Pharmaceutical Research and Development

A UK based new start-up is developing a unique method for testing out the impact of drugs on the cardio-vascular system without resorting to animal testing or through clinical trials of an early-stage human. The company we are talking about is Inocardia, a spin-out from the University of Coventry. Having attracted sufficient funding from the Mercia Fund Management, this organization is still in the process of shaping up the model and commercializing their line of business. The model that they use takes up samples of the human heart attached to a rig. The cardiac tissue is elongated and contracted through electric impulse stimulation so as to mimic a working human heart.Drugs to be trialed are then administered to the tissue to keep a track of adverse effects – a test that could have been...

Apr72016 by Pharmaceutical TechNo Comments

Low-Cost Genome Sequencing

BioPharma, Biotechnology, Cheminformatics, Drug Development, Drug Discovery, Economic and Regional Development, Pharma Industry

In Silicon Valley, Moore's law appears to remained on equivalent balance with the regular laws classified by Isaac Newton. Intel prime supporter Gordon Moore's notorious perception that registering power has a tendency to twofold — and that its value hence parts — like clockwork has held valid for about 50 years with just minor update. Yet as a model of quick transform, it is the focus of energetic ill-use from genome analysts. In many presentations over the past few years, researchers have contrasted the slant of Moore's law and the quickly dropping expenses of DNA sequencing. For some time they kept pace, however since something like 2007, it has not even been close. The cost of sequencing a normal human genome has plunged from about Us$10 million to a couple of thousand dollars in only...

Apr32016 by Pharmaceutical TechNo Comments

Why is Good Tablet Design so Important and How to Achieve it?

Combinatorial Chemistry, Drug Development, Pharmaceutical Chemicals and Intermediates, Pharmaceutical Excipients and Drug Formulation, Tableting and Encapsulation

Detailed design of pharmaceutical and nutraceutical tablets is essential in order to produce robust tablets with bespoke designs. Tablet manufacturers should not overlook tablet design because it is key to the quality of the end product. “With sufficient fore-thought and consideration, most potential tablet making problems can be eliminated at the early stage of design. ” I Holland. Good tablet design is extremely important; it has an impact upon anti-counterfeiting, tooling strength,tablet coating, durability and functionality. Good tablet design helps to avoid downstream manufacturing problems such as tablet sticking, picking, lamination, capping and premature tooling failures. It is essential to consider these at the beginning of the process, ensuring a problem free, high quality, end...

Mar212016 by Pharmaceutical TechNo Comments

Weighing and Dispensing Process and Technology in Pharma Industries

Drug Development, Pharmaceutical Chemicals and Intermediates, Pharmaceutical Excipients and Drug Formulation, Pharmaceutical Instrumentation and Controls, Pharmaceutical Quality Assurance, Pharmaceutical Research and Development

Weighing and dispensing process in pharma industries occupies a high priority position. Over the last decades, increased regulations on the manufacturing processes in pharma manufacturing industries led the focus and result is the advanced technology and stringent policies and frameworks. The pharmaceutical companies can increase the speed and accuracy of their operations with weigh and dispense process technology. While, weighing and dispensing of solids and liquids is a very common activity throughout the pharmaceutical industry processes. Traditionally, workers dispense pharma materials by hand-scooping solids and pumping or pouring liquids. This is generally conducted in a warehouse during chemical production or in a pharmacy during pharmaceutical dosage-form manufacturing. The chanc...

Feb252016 by Pharmaceutical TechNo Comments

Clinical Research: Ethical or Unethical?

Clinical Trials, Drug Development, Pharmaceutical Excipients and Drug Formulation, Pharmaceutical Research and Development

Everybody believes that informed consent makes clinical research ethical. However, informed consent is neither necessary nor sufficient for ethical clinical research. Drawing on the basic philosophies underlying major codes, declarations, and other documents relevant to research with human subjects, The aspects which make Clinical Research Ethical: Value: enhancements of health or knowledge must be derived from the research; Scientific validity: the research must be methodologically rigorous. Fair subject selection: scientific objectives, not vulnerability or privilege, and the potential for and distribution of risks and benefits, should determine communities selected as study sites and the inclusion criteria for individual subjects. Favorable risk-benefit ratio: within th...